Comparison of abnormal vertebral pedicles between dystrophic and nondystrophic scoliosis in neurofibromatosis type 1

English Keywords:Abnormal pedicles  Neurofibromatosis type 1  Scoliosis  Dystrophic  Nondystrophic

English Abstract:

  【Abstract】 Objectives: To explore the prevalence of abnormal vertebral pedicles in neurofibromatosis type 1 (NF1-S), and to compare the difference between dystrophic and nondystrophic scoliosis. Methods: Based on computed tomography images, vertebral pedicles from 30 patients with NF1-S with dystrophic scoliosis and 30 patients with NF1-S with nondystrophic scoliosis were carefully measured. Pedicle morphology was classified into five types: type A, cancellous channel >4mm; type B, cancellous channel from 2mm to 4mm; type C, cancellous channel <2mm with entirely cortical channel ≥2mm; type D, cortical channel <2mm; type E, absent pedicle. Type B, C, D and E were defined as abnormal. The incidence of anomalous pedicles in different NF1-S patients and their distribution in the area of lateral convex arc were compared. Results: The total prevalence of abnormal pedicles in patients with NF1-S was 67.5%(1376/2040), including type B 39.6%(807/2040), type C 22.3%(455/2040), type D 3.6%(74/2040) and type E 2.0%(40/2040). The prevalence of abnormal pedicles in the arc region was as high as 75.3%(975/1294), which accounted for 70.9% of total abnormal pedicles(975/1376). The prevalence of abnormal pedicles of dystrophic scoliosis was much higher than that of nondystrophic scoliosis(72.3% vs. 62.6%, P<0.05). Conclusions: Abnormal pedicles in patients with NF1-S mainly concentrate in the arc region. The prevalence of abnormal pedicles of dystrophic scoliosis is significantly higher than that of nondystrophic ones.