Association between MMP-3 rs3025058/IL-6 rs1800795 single nucleotide polymorphisms and idiopathic scoliosis: a Meta-analysis

English Keywords:Idiopathic scoliosis  Matrix metalloproteinase-3  Interleukin-6  Gene polymorphism  Meta-analysis

English Abstract:

  【Abstract】 Objectives: To explore whether IL-6 rs1800795 and MMP-3 rs3025058 single nucleotide polymorphisms(SNP) are associated with the susceptibility to idiopathic scoliosis(IS). Methods: Databases including Pubmed, Cochrane Library, Web of Science, Databases@Ovid(OVID), China National Knowledge Infrastructure(CNKI) and Wanfang databases were used to collect case-control studies which evaluated the association between IL-6 rs1800795 and MMP-3 rs3025058 SNP from inception to July 31, 2017. The quality of the included literatures was evaluated by Newcastle-Ottawa Scale. After the data of the allelic frequency and genotypic frequency among the SNPs were abstracted, both overall and stratified(by population) Meta-analyses were performed by Revman 5.3 software. Summary odd ratios(OR) and corresponding 95% confidence intervals(95%CI) were estimated in allelic and genotypic comparisons. Besides, subgroup analysis between Caucasian and Asian populations was conducted according to ethnicity. Results: Six English literatures and one Chinese literature were included, methodological quality assessment of all which were more than or equal to 5 stars. Seven studies meeting the inclusion criteria contained 1349 cases and 1609 controls for Meta-analysis. The results showed allele 5A and genotype 5A5A of MMP-3 rs3025058 were significantly associated with IS: 5A vs. 6A, OR=1.18, 95%CI: 1.03-1.35, P=0.01; 5A5A vs. 6A6A, OR=1.68, 95%CI: 1.23-2.30, P=0.001; 5A5A vs. 5A6A+6A6A, OR=1.64, 95%CI: 1.08-2.47, P=0.02. When stratified into Caucasian and Asian populations, there was significant association in both populations, but the results in Caucasian population were closer to overall: in Asian population, 5A5A vs. 6A6A, OR=1.85, 95%CI: 1.13-3.02, P=0.01; 5A5A vs. 5A6A+6A6A, OR=1.81, 95%CI: 1.11-2.97, P=0.02; in Caucasian population, 5A vs. 6A, OR=1.22, 95%CI: 1.00-1.49, P=0.05; 5A5A vs. 6A6A, OR=1.57, 95%CI: 1.05-2.36, P=0.003. But no significant association was detected between IL-6 rs1800795 and IS(C vs. G, OR=0.71, 95%CI: 0.38-1.30, P=0.27). Conclusions: Our results suggest that the allelic of 5A and genotype 5A5A in MMP-3 rs3025058 are significantly associated with IS susceptibility especially in Caucasian population. Besides, the currently available studies can not supply enough evidence to prove an overall significant association of IL-6 rs1800795 polymorphism with risk of IS.