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| JIANG Shudong,HONG Yi,ZHANG Junwei.[J].Chinese Journal of Spine and Spinal Cord,2017,(2):175-180. |
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| Received:November 28, 2016 Revised:January 20, 2017 |
| English Keywords:Hemisection spinal cord injury Phrenic nerve Phrenic nerve stimulator Rabbit Diaphragm |
| Fund:首都卫生发展科研专项课题（编号：2011-6001-01） |
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| English Abstract: |
| 【Abstract】 Objectives: To develop a tailored implantable phrenic nerve stimulator, and to evaluate the effectiveness and compatibility of stimulator in the setting of rabbit cervical spinal cord hemisection injury model. Methods: Thirty New Zealand white rabbits were randomly divided into control group(group A) and experimental group(group B), with 15 rabbits in each group. C3 spinal cord hemisection injury model was established, which resulted in ipsilateral diaphragm paralysis confirmed by MEP. Simulator was implanted into the posterior triangle of neck between both groups, then electrical stimulation was regularly applied to the phrenic nerve only in group B. Blood gas was analyzed before and after injury. Diaphragm and phrenic nerve were collected for morphological observation at 1, 2, 4 weeks after injury. Results: The value of PaO2 got down and PaCO2 went up one week after injury in both groups with no statistically difference(P>0.05). PaO2 returned to the normal range and PaCO2 slightly decreased from two to four weeks after injury in group B, while PaO2 decreased and PaCO2 increased continuously at the same time in group A. There was a significant difference between group A and B. The dimension of diaphragm muscle cells in group A was significantly less than that in group B at 2 and 4 weeks. The structures of phrenic nerve in group B were well preserved compared with group A. Conclusions: The customized implantable phrenic nerve stimulator can facilitate the improvement of respiratory dysfunction resulted from rabbits cervical cord hemisection injury, in the meanwhile better biological compatibility is observed. The potential mechanism of this benefit might be that electrical stimulation postpones or reverses the atrophy of diaphragm and degeneration of phrenic nerve as well. |
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