The correlation between HIZ on MRI T2-weighted and positive outcome of discography: a Meta-analysis

English Keywords:MRI  High intensity zone  Discography  Discogenic low back pain  Meta-analysis

English Abstract:

  【Abstract】 Objectives: To assess the correlation between high intensity zone(HIZ) of lumbar MRI and discography. Methods: A computer-based online search of Medline, EMBASE, Cochrane CENTRAL (1st Quarter 2013), ScienceDirect, OVID, SpringerLink and The China Biological Medicine Database(from January 1973 to April 2013). The included trials were lumbar pain patient undergoing discography and MRI, and the correlation between HIZ and discography positive was observed. The literature was screened out according to the included standard. The quality of included trials was evaluated. RevMan 5.1.1 was used for data analysis. Results: Eleven studies were included. The results of Meta-analysis indicated that outstanding relativity and statistically significant difference were observed between HIZ and abnormal morphology of disc[OR=47.79, 95%CI(17.07, 133.77), P<0.00001], HIZ and pain reproduction[OR=8.65, 95%CI(4.92, 15.23)，P<0.00001], HIZ and abnormal morphology pain reproduction[OR=8.65, 95%CI(4.92, 15.23), P=0.007]. Conclusions: The occurence of HIZ on lumbar MRI T2-weighted image indicates abnormal morphology of the disc. There is obvious relationship between HIZ and pain reproduction. HIZ can be a very effective index to determine responsible level discogenic low back pain.