The risk factors of onset of osteoporotic vertebral compression fractures after percutaneous vertebroplasty

English Keywords:Percutaneous vertebroplasty  Vertebral compression fractures  Osteoporosis  Intradiscal cement leakage, 25-(OH)D

English Abstract:

  【Abstract】 Objectives: To explore the risk factors associated with the onset of vertebral compression fractures after percutaneous vertebroplasty(PVP). Methods: A total of 76 patients undergoing ＰＶＰ due to osteoporotic vertebral compression fractures(OVCFs) from March 2010 to March 2013 was retrospectively analyzed, the data included age, body mass index, bone mineral density, number of initial vertebral fractures, bone cement leakage into discs, use of antiosteoporotic medications. And the data of their bone metabolistic markers and 25-(OH)D levels of different periods after PVP were also assessed. Results: 17 patients experienced 19 subsequent fractures. Univariate analysis showed that bone cement injection volume, bone cement leakage into discs, use of antiosteoporotic medications and levels of 25-(OH)D were the variables associated with the onset of vertebral fractures(P<0．05)．　In contrast, age, sex, operation approach, body mass index and bone mineral density showed no significant differences. Multiple-factors logistic regression analysis showed that bone cement leakage into discs, lower level of 25-(OH)D and absence of antiosteoporotic medication were the predominant correlative factors associated with the onset of vertebral fracture. Conclusions: The most important risk factors associated with onset of ＯVCFs are absence of antiosteoporotic medication and bone cement leakage into discs and low serum 25-(OH)D level.