Influence of monocyte chemoattactant protein-1-2518 gene polymorphism on susceptibility of spinal tuberculosis

English Keywords:Monocyte chemoattactant protein-1(MCP-1)  Gene polymorphism  Spinal tuberculosis

English Abstract:

  【Abstract】 Objectives: To investigate the association between monocyte chemoattactant protein-1-2518 gene polymorphism and the susceptibility to spinal tuberculosis in Han people of Humnan province. Methods: 334 patients with spinal tuberculosis(case group) and 336 healthy volunteers(control group) were recruited in our hospital from December 2004 to August 2012. Their MCP-1-2518 genotype were detected by polymerase chain reaction and sanger DNA sequencing technology. The differences in genotype frequencies between two groups were compared using the chi-square test. The Odds ratio(OR) and 95% confidenceinterval(CI) were calculated too. Results: The genotype frequencies of GG, AG, AA were 37.1%, 50.3%, 25.6% in case group, while they were 25.6%, 54.2%, 20.2% in control group. There were significant differences between two groups (P<0.05). The MCP-1-2518 GG genotype were overexpressed in case group, the odds ratio was 2.334(95% CI: 1.455-3.746). Furthermor, there was a significant difference between groups in regard to the frequenceies of the MCP-1-2518 allelotype. In case group, the frequency of the G allelotype was 62.3%, which was significantly higer than the corresponding value for the control group(52.7%). The odds ratio was 1.483(95% CI: 1.193-1.844). Conclusions: The MCP-1-2518 GG genotype and MCP-1-2518 G allelotype may be associated with susceptibility to spinal tuberculosis in Han people of Hunan province.