Interleukin-17 receptor C gene polymorphism associated with the susceptibility of adolescent idiopathic scoliosis in a Chinese Han population

English Keywords:Adolescent idiopathic scoliosis  Interleukin-17 receptor C gene  Single nucleotide polymorphism  Genotype

English Abstract:

  【Abstract】　Objectives: To investigate the association of interleukin-17 receptor C(IL-17RC) gene polymorphisms with the susceptibility of adolescent idiopathic scoliosis(AIS) in Chinese Han population. Methods: A total of 529 Chinese girls with AIS and 512 healthy age-matched controls were recruited in this study. Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique was used to detect the genotype and allele frequency distribution in single nucleotide polymorphism(SNP) rs708567 and rs279545 in both AIS group and control group. Results: The sample size had an 81% power to detect the AIS-relevant SNP within the IL-17RC gene. The genotype frequencies showed no significant deviation from the Hardy-Weinberg equilibrium in either AIS group or control group. For SNP rs708567, both GG genotype and G allele frequencies in AIS patients were significantly higher than those of normal controls(GG: 90.17% vs. 85.55%, P=0.023; G: 95.1% vs. 92.8%, P=0.028). In addition, the study showed that GG genotype of IL-17RC gene was independently associated with the risk of scoliosis(odds ratio=1.55; 95% CI: 1.45-3.11). While, for SNP rs279545, no statistically significant differences were found either in genotype or allele frequencies between AIS patients and controls. Conclusions: IL-17RC gene rs708567 polymorphism is associated with the susceptibility of adolescent idiopathic scoliosis in Chinese Han population.