YUAN Shuo,QIU Yong,ZHU Feng.The bone mineral density in adolescents with neurofibromatosis 1 scoliosis[J].Chinese Journal of Spine and Spinal Cord,2011,(4):280-284.
The bone mineral density in adolescents with neurofibromatosis 1 scoliosis
Received:November 16, 2010  Revised:December 04, 2010
English Keywords:Neurofibromatosis 1  Scoliosis  Adolescent  Bone mineral density
Fund:基金项目:江苏省自然科学基金项目(编号:BK2010109)
Author NameAffiliation
YUAN Shuo Spinal SurgeryAffiliated Gulou HospitalNanjing University Medical SchoolNanjing210008China 
QIU Yong 南京大学医学院附属鼓楼医院脊柱外科 210009 江苏省南京市 
ZHU Feng 南京大学医学院附属鼓楼医院脊柱外科 210010 江苏省南京市 
王守丰  
王 斌  
俞 杨  
朱泽章  
钱邦平  
孙 旭  
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English Abstract:
  【Abstract】 Objective:To evaluate the bone mineral density(BMD) in adolescents with scoliosis secondary to neurofibromatosis 1(NF1) and the relationship between BMD and severity and type of scoliosis.Method:From March 2008 to April 2010,23 adolescents suffering NF1 scoliosis were reviewed retrospectively.All cases were divided into 2 groups based on abnormality,14 patients(group A) with dystrophic thoracic scoliosis had the mean age of 13.4 years(range,10 to 18 years) and mean Cobb angle of 84.1°(range,60° to 132°),while 9 patients(group B) with non-dystrophic thoracic scoliosis had the mean age of 13.2 years(range,11 to 16 years) and mean Cobb angle of 71.4°(range,40° to 87°).Meanwhile,24 volunteers with the mean age of 14.7 years(range,l0 to 17 years) were selected as control(group C).The BMD of the lumbar spine(L2-L4) and the proximal femur was measured using dual energy X-ray absorptiometry in all cases.BMD was compared among three groups by one-way ANOVA analysis.The relationship between BMD and Cobb angle within group A and group B was assessed using Pearson correlation analysis.Result:No differences in terms of age and sex ratio were noted in three groups(P>0.05).The Cobb angle and the BMD of the lumbar spine and the proximal femur in group A showed no significant differences compared with group B(P>0.05).However,both groups A and B showed significant lower BMD than group C(P<0.05),and the diminution of BMD in lumbar spine was more remarkable than that in proximal femur.The values of BMD in group A and B showed no relationship with Cobb angle.Conclusion:The decreased BMD exists in adolescents with dystrophic or non-dystrophic scoliosis secondary to NF1.However,the BMD is not correlative with the type or the severity of scoliosis.
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