CT-guide interstitial iodine-125 seed implantation for metastatic spine tumor

English Keywords:CT-guide  Iodine-125 seed  Spinal tumor  Metastasis  Brachytherapy

English Abstract:

  【Abstract】 Objective：To investigate the value of CT-guide interstitial iodine-125 seed implantation for metastatic spine tumor.Method：14 patients with metastatic spine tumor，who did not have surgery，chemotherapy or external beam radiotherapy，underwent CT-guide interstitial iodine-125 seed implantation.Three-dimensional treatment system was used to determine the implantation plan.Different needles placement（0.5-1.0cm apart），number and distribution of seeds were determined according to the images，tumor sizes and sensitivity to radioactive rays. The mean number of seeds was 72（range，26-145），and the mean radioactive activity was 0.70mCi（range，0.50-0.80mCi）.Three-dimensional treatment system was used for dose validation.Result：The mean follow-up was 12.0 months （range，1 to 75 months）.The local control rate was 50.0%.The mean local control time and survival time was 26.0 months and 11.0 months repectively.The 1-year，2-year and 3-year local controls were 62.5%，50.0% and 37.5% respectively.The 1-year，2-year and 3-year survival rates were 50.0%，41.7% and 20.8% respectively.Preservation and recovery ratio of meurofunction were 92.9% and 71.4% respectively.Effect and complete pain relief ratio were 78.6% and 64.3% respectively.Conclusion：CT-guide interstitial iodine-125 seed implantation is minimally invasive and less-complication for spine metastatic tumor，which can be used as an alternative to convention surgery.