Correlative factors of non-surgical vertebral fractures after percutaneous vertebroplasty for osteoporotic vertebral compression fractures

English Keywords:Osteoporotic vertebral compression fractures  Percutaneous vertebroplasty  Non-surgical vertebral fractures  Correlative factors

English Abstract:

  【Abstract】 Objective：To investigate the correlative factors associated with non-surgical vertebral fractures after percutaneous vertebroplasty（PVP） for osteoporotic vertebral compression fractures（OVCFs）.Method：From January 2007 to March 2010，42 out- and in-patients with non-surgical vertebral fractures after PVP for OVCFs were included in this study.There were 8 males and 34 females with the average age of 67.3 years（range，55-82 years old）.All patients underwent X-Ray and MRI to confirm the onset of non-surgical segment fracture.68 patients without the non-surgical segment fracture after PVP were selected as the control, who were 17 males and 51 females with an average age of 60.1 years（range，52-75 years old）.The bone mineral density（BMD） of lumbar spine was measured by dual-energy X-ray absorptiometry，and the patients′ age，sex，body mass index（BMI），operative site and approach，administration of glucocorticoids for more than 1 year or without were recorded.The correlative factors associated with the non-surgical vertebral fractures were analyzed.Result：Univariate analysis showed statistically significant differences（P＜0.05） between two groups with respect to age，BMD，whether to take glucocorticoids,whereas no significant differences（P＞0.05） with regard to sex，BMI，operative site and approach.Multiple logistic regression analysis showed old age，BMD≤-2.5SD，administration of glucocorticoids for more than 1 year were the predominant risk factors associated with non-surgical segment fracture，with the OR value of 3.775，5.980 and 3.401 respectively（P＜0.05）.Conclusion：Old age，osteoporosis and administration glucocorticoids for more than 1 year are the relative risk factors of non-surgical vertebral fractures after PVP for OVCFs.