The correlation between Cobb angle and bone mineral density in patients with adolescent neurofibromatosis 1 scoliosis/

English Keywords:Neurofibromatosis 1  Scoliosis  Adolescent  Osteoporosis

English Abstract:

  【Abstract】 Objective：To evaluate the relationship between bone mineral density（BMD） and the patients with scoliosis secondary to neurofibromatosis 1（NF-1）.Method：18 individuals with adolescent neurofibromatosis 1 scoliosis with mean age of 14.9 years（range，10 to 18 years） and mean Cobb angle of 81.4°（range，40° to 132°） were reviewed retrospectively，while 25 adolescents with mean age of 15.6 years（range，11 to 19 years）undergoing spinal surgery were selected as control.BMD of the lumbar spine（L2-L4） and proximal femur was measured using dual energy X-ray absorptiometry in both groups.BMD in two groups was tested by t-test，and the relationships between BMD of the adolescent neurofibromatosis 1 scoliosis and Cobb angle was assessed using correlation analysis.Result：No age and sex ratio related difference were noted in two groups（P>0.05）.However，the BMD of the lumbar spine and proximal femur in patients who had adolescent neurofibromatosis 1 scoliosis was significantly different from those in control group（P＜0.01），in patients with NF-1，the reduction of BMD in lumbar spine was more remarkable than that in proximal femur.Furthermore，the BMD of the lumbar spine and proximal femur in NF-1 patients had no significant correlations with Cobb angle（P>0.05）.Conclusion：Osteoporosis in patients with adolescent neurofibromatosis 1 scoliosis is not correlative with the severity of the neurofibromatosis 1 scoliosis.However，it may be caused by the inner mechanism.