Meta-analysis of the relationship between Modic changes and low back pain

English Keywords:Modic changes  Low back pain  Meta analysis

English Abstract:

  【Abstract】　Objective：To determine the relationship between Modic changes and low back pain（LBP） through Meta-analysis.Method：MEDLINE，EMBASE and Cochrane Controlled Clinical Trials Register databases were carefully　searched to determine relevant papers.The parameter index for Meta-analysis included the number of symptomatic lumbar discs which pain can be provoked by discography or not（with pain similar to the primary） as well as the number with Modic changes among them.The results were brought to Review Manager 4.2（download from Cochrane Library） and measured using odds ratio（OR） under Random-effect model for sensitivity analysis.Further comparative analysis between the subgroups was performed thereafter.Result：After screening out，a total of 6 papers were meet our inclusion criterion for Meta-analysis.There were 966 cases and 3026 discs.The combined OR value for pain group and painless group after discography was 3.66（95%CI，1.46-9.15）.While the combined OR value for type 1 and type 2 Modic change in pain group after discography was 1.31（95%CI，0.35-4.96）.Conclusion：There is higher incidence rate of Modic changes in LBP patients compared with those in no LBP patients.No evidence available supports type 1 Modic changes is more relevant to low back pain.