基于MRI的骨质疏松椎体压缩骨折患者椎旁肌特征定量分析研究

MRI-based quantitative analysis of paraspinal muscle characteristics in patients with osteoporotic vertebral compression fractures

中文关键词:  骨质疏松性椎体压缩骨折  脊柱椎旁肌肉  脂肪浸润率  椎体骨质量评分  磁共振成像

英文关键词:Osteoporotic vertebral compression fractures  Paraspinal muscle  Fatty infiltration  Vertebral bone quality score  Magnetic resonance imagine

中文摘要:

  【摘要】 目的：对比分析骨质疏松性椎体压缩性骨折（osteoporotic vertebral compression fracture，OVCF）患者和非OVCF患者腰椎MRI特征，脂肪浸润率（fatty infiltration，FI），探讨其与骨折发生的关系。方法：回顾性分析46例OVCF患者（70.67±11.99岁；男11例，女35例）的临床资料，以46例年龄（70.76±5.40岁）、性别（男11例，女35例）匹配的不伴OVCF的患者作为对照组。在腰椎MRI上测量椎旁肌FI、肌肉横截面积（cross-sectional area，CSA）和椎体骨质量（vertebral bone quality，VBQ）评分。采用独立样本t检验比较OVCF组与对照组之间的差异，并进行回归分析，探索OVCF发生的风险因素。结果：OVCF组患者的VBQ评分显著高于对照组（P<0.05），椎旁肌FI显著高于对照组（P<0.05）。两组椎旁肌CSA无显著差异。VBQ评分（OR=1.963，P<0.01）和L4代表的椎旁肌FI（OR=1.203，P<0.01）是OVCF的独立风险因素。结论：OVCF患者的腰椎MRI参数与非OVCF的骨质疏松患者相比，VBQ评分及椎旁肌FI均较大，VBQ评分、椎旁肌FI是OVCF的独立风险因素，预防OVCF同时应重视对椎旁肌功能的改善。

英文摘要:

  【Abstract】 Objectives: To compare and analyze the MRI characteristics and fatty infiltration(FI) of the lumbar spine in patients with and without osteoporotic vertebral compression fracture(OVCF) to explore their relationships with fracture. Methods: 46 patients with OVCF(70.67±11.99 years old; 11 males, 35 famales) were retrospectively analyzed, and 46 age- (70.76±5.40) and sex- (11 males, 35 famales) matched osteoporotic patients without OVCF were taken as the control group. Paravertebral muscle FI, cross-sectional area(CSA), and vertebral bone quality(VBQ) score were measured on lumbar MRI. Independent samples t-test was used to compare the differences between the OVCF group and the control group, and regression analysis was performed to explore the risk factors for the development of OVCF. Results: Patients in the OVCF group had significantly higher VBQ scores(P<0.05) and significantly higher paravertebral muscle FI(P<0.05) than those in the control group. There was no significant difference in CSA of paravertebral muscles between the two groups. VBQ score(OR=1.963, P<0.01) and FI of paravertebral muscles represented by L4(OR=1.203, P<0.01) were the independent risk factors for OVCF. Conclusions: The MRI parameters of lumbar spine in patients with OVCF had greater VBQ scores and paravertebral muscle FI compared with the osteoporotic patients without OVCF; VBQ scores and paravertebral muscle FI are the independent risk factors for OVCF, and attentions should be paid to improve paravertebral muscle functions in the meantime of preventing OVCF.