基于MRI定量非对称回波最小二乘估算水脂分离技术的成人腰椎骨髓脂肪与年龄和性别的相关性研究

Correlation study of age, gender and lumbar vertebral marrow fat in adults based on MRI iterative decomposition of water and fat with echo asymmetry and least-squares estimation image quantitation imaging technique

中文关键词:  磁共振成像  定量非对称回波最小二乘估算水脂分离技术  腰椎  骨髓  脂肪组织

英文关键词:Magnetic resonance imaging  Iterative decomposition of water and fat with echo asymmetry and least-squares estimation image quantitation  Lumbar vertebrae  Bone marrow  Adipose tissue

中文摘要:

  【摘要】 目的：基于MRI定量非对称回波最小二乘估算水脂分离（iterative decomposition of water and fat with echo asymmetry and least-squares estimation image quantitation，IDEAL-IQ）技术探讨成年人腰椎不同节段骨髓脂肪与年龄和性别的关系。方法：收集298例受检者的MRI IDEAL-IQ脂肪分数图像，其中男性138例，女性160例，年龄 20～69 岁。将所有患者按照每10岁为一个年龄段分为5 组：20～29岁（20~组），男24例，女20例；30～39岁（30~组），男47例，女39例；40～49岁（40~组），男36例，女47例；50～59岁（50~组），男20例，女37例；60～69岁（60~组），男11例，女17例。使用脂肪分数图在GE ADW4.6工作站测量L1~L5的骨髓质子密度脂肪分数（proton density fat fraction，PDFF）。结果：同一年龄组、不同性别间PDFF存在差异，20~、30~、40~组人群中，男性L1~L5椎体PDFF均高于女性（P<0.05）；50~组人群中男性L1~L5椎体PDFF与女性的差异无统计学意义（P>0.05）；60~组人群，男性L1~L5椎体PDFF均低于女性（P<0.05）。腰椎椎体PDFF与年龄呈正相关，女性（r=0.72，P<0.05）相关性高于男性（r=0.32，P<0.05）。从20~69岁，男性L4 PDFF增长率最大（21.08%），女性L1 PDFF增长率最大（65.68%）；男性各椎体PDFF增长主要集中在30~及50~组，其中L1、L4、L5椎体PDFF在50~组增长率最大，L2、L3椎体PDFF在30~岁组增长率最大；女性各椎体PDFF在30~组呈轻微下降趋势，此后各椎体PDFF逐渐升高，增长主要集中在40~、50~、60~三个年龄组，其中50~组增长率最大。结论：成人不同年龄组男女性各椎体脂肪分布存在差异，椎体PDFF增长率也有所不同；腰椎不同节段椎体PDFF均与年龄呈正相关。

英文摘要:

  【Abstract】 Objectives: To investigate the relationships between vertebral marrow fat in lumbar spine and age and gender in adults using iterative decomposition of water and fat with echo asymmetry and least-squares estimation image quantitation(IDEAL-IQ) magnetic resonance imaging technology. Methods: The IDEAL-IQ fat fraction images from 298 subjects(Male: 138, Female: 160, age range: 20-69 years old) were collected. All the patients were divided into 5 groups based on age, with each group spanning a range of 10 years: age range 20-29 years(Twenties): 24 males, 20 females; 30-39 years(Thirties): 47 males, 39 females; 40-49 years(Forties): 36 males, 47 females; 50-59 years(Fifties): 20 males, 37 females; 60~69 years(Sixties): 11 males, 17 females. The bone marrow proton density fat fration(PDFF) were measured using GE ADW4.6 processing work station. Results: In the same age group, there were differences in vertebral bone marrow PDFF between genders. PDFF of L1-L5 vertebrae was significantly higher in males than females in twenties, thirties and forties(P<0.05). In the fifties, there was no statistically significant difference in the L1-L5 vertebrae PDFF between males and females(P>0.05); while in the sixties, the PDFF of the L1-L5 vertebrae was lower in males than that in females(P<0.05). The PDFF of lumbar vertebral bone marrow was positively correlated with age, with a higher correlation observed in females(r=0.72, P<0.05) than that in males(r=0.32, P<0.05). From the age of 20 to 69, the L4 vertebra PDFF in males had the highest growth rate(21.08%), while the L1 vertebra PDFF in female had the highest growth rate(65.68%). For males, the growth of PDFF was primarily concentrated in the thirties and fifties; The PDFF of L1, L4, and L5 vertebrae showed the largest increase in the fifties, while that of L2 and L3 vertebrae had the highest increase rate in the thirties. For females, vertebral PDFF showed a slight decrease trend in the group of thirties, which gradually increased subsequently in all vertebare in the group of forties, fifties, and sixties, with the largest increase rate observed in the fifties. Conclusions: There are differences in vertebral fat distribution between males and females across different age groups, and the growth rates of vertebral PDFF also vary; the PDFF of vertebral bodies in different segments of the lumbar spine is positively correlated with age.