施建党,王自立,耿广起,王 沛.单纯应用抗结核药物治疗早期脊柱结核的疗效观察[J].中国脊柱脊髓杂志,2011,(10):798-801. |
单纯应用抗结核药物治疗早期脊柱结核的疗效观察 |
中文关键词: 脊柱结核 抗结核药物 早期 治疗 |
中文摘要: |
【摘要】 目的:探讨单纯应用抗结核药物治疗早期脊柱结核患者的疗效及适应证。方法:回顾性分析宁夏医科大学附属医院2000年1月~2007年6月收治的36例督导下单纯应用抗结核药物治疗脊柱结核患者的治疗情况,治疗方案为联合用药(3HRZS/1~15HRZ),疗程4~18个月。随诊观察临床表现、影像学(椎体愈合、后凸畸形)变化、神经功能改变及抗结核药物对机体的不良反应,根据疗效情况及时调整疗程。结果:全部病例随访3~5年。36例中,在完成4个月的超短程化疗疗程后,16例达到治愈;未愈者用药延长至9个月,14例治愈;其余6例通过长程化疗18个月获得治愈。8例(22%)出现药物副作用,通过暂停用抗结核药物并配以相应药物治疗恢复正常。末次随访患者全身低热消失、体重增加;局部疼痛症状减轻或消失;椎体骨性融合;6例后凸畸形轻度加重(均<30°,支具制动);血沉下降至正常范围。结论:对于早期脊柱结核病例,单纯应用规范的抗结核药物治疗能够取得满意的疗效。 |
Chemotherapy alone for early-stage spinal tuberculosis |
英文关键词:Spinal tuberculosis Anti-TB chemotherapy Early stage Treatment |
英文摘要: |
【Abstract】 Objective:To evaluate the effect and indication of chemotherapy alone for early-stage spinal tuberculosis.Method:From January 2000 to June 2007,36 patients from the General Hospital of Ningxia Medical University suffering from spinal tuberculosis undergoing anti-TB chemotherapy alone were retrospectively reviewed.The chemotherapeutic regimen was combined medication(3HRZS/1-15HRZ),and the course was 4~18 months.The effect of anti-tuberculosis,including clinical manifestation,the phantom study(bone heals,raised abnormal),the neurofunction and complications related to tuberculosis chemotherapy were reviewed.The chemotherapy course can be adjusted individually according to the result of following up.Result:All cases were followed up for 3-5 years.Of them,16 patients healed with less than 4 months of the short-course chemotherapy.The patients with poor outcome had their course extended to 9 months.14 patients healed completely.The remaining 6 patients healed by 18 months long-range chemotherapy.At final follow-up,all patients had body temperature recovered to normal,weight increased,the local pain disappeared,and the bony union;while 6 cases had kyphosis angle increased(<30°,application of external fixation).All patients had ESR decreased to normal.8 cases(22%) presented with the medicine related complications,which resolved after ceasing chemotherapy and responsive intervention.Conclusion:The routine chemotherapy alone is reliable for early-stage spinal tuberculosis. |
投稿时间:2010-12-18 修订日期:2011-03-28 |
DOI:10.3969/j.issn.1004-406X.2011.10.798.3 |
基金项目:基金项目:国家自然科学基金项目(81060149);宁夏自然科学基金项目(NZ10117) |
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