退行性腰椎侧凸与骨质疏松症的相关性研究

Correlative study of degenerative lumbar scoliosis and osteoporosis

中文关键词:  骨质疏松症  退行性腰椎侧凸  双能X线吸收法  相关性

英文关键词:Osteoporosis  Degenerative lumbar scoliosis  Dual-energy x-ray absorptiometry  Correlation

中文摘要:

  【摘要】 目的：分析成人退行性腰椎侧凸与骨质疏松的相关性。方法：2004年1月至2009年6月门诊及病房共收治退行性腰椎侧凸患者69例，男6例，女63例；年龄51~82岁，平均69.3岁；所有患者均行X线、MRI检查，确诊并记录患者侧凸Cobb角；对照组50例，男9例，女41例，均为非腰椎侧凸患者，其中腰椎管狭窄症37例，腰间盘突出症8例，腰椎滑脱症4例，腰椎管内占位1例，平均年龄62.6岁。应用双能X线吸收法测定腰椎（L2～Ｌ4）及股骨颈、股骨粗隆和Ward′s三角骨密度值及T值，分析患者年龄、Cobb角与对应T值的相关性。结果：在69例退行性腰椎侧凸患者中，平均T值为-2.8±1.9，分布在-0.9～-4.7之间，合并骨质疏松52例，骨量减少14例；对照组平均T值-1.2±1.6，分布在0.4～-2.8之间；两组比较差异有显著性（P<0.05）。骨质疏松程度与年龄呈明显正相关，而与Cobb角无相关。结论：骨质疏松症是退行性腰椎侧凸发病的危险因素，同时骨质疏松程度随着年龄的增大而增加，但与侧凸程度无明显相关。

英文摘要:

  【Abstract】 Objective：To investigate the correlation between degenerative scoliosis and osteoporosis.Method： From Jan.2004 to Jun.2009，69 patients diagnosed with degenerative scoliosis from out-patient and wards were included in the group.There were 6 males and 63 females with an average age of 69.3 years（range，from 51 to 82 years）.All the patients underwent X-Ray and MRI examines to comfirm the diagnosis，and Cobb angle was recorded respectively.Control group had 50 cases without scoliosis，including 37 spinal stenosis，8 lumbar disc herniation，4 spondylolisthesis and 1 lumbar spinal tumor.The bone density of lumbar，femoral neck， trochanter，Ward′s triangle regions was measured with dual-energy x-ray absorptiometry.Observe the T-scores of different ages and Cobb angles were observed，to analyze their correlations.Result：Of the 69 cases with degenerative scoliosis，the average T-score was -2.8±1.9（range，from -0.9 to -4.7），52 cases combined with osteoporosis，14 cases combined with osteopenia，the average T-score in the control group was -１.２±1.６（range，from 0.4 to -2.8）.Significant difference was found among the mean t-scores of lumbar and proximal femoral regions of the groups（P<0.05）.According to the comparision of T-score in different ages and Cobb angles，the T-score existed a positive correlation with age，and zero correlation with Cobb angle.Conclusion：Osteoporosis is a risk factor for degenerative scoliosis，there exists a significant correlation.The severity of osteoporosis doesn′t correlate with curve magnitude，but increases with the increasing of age.