骨形成蛋白-2/7促进腰椎融合效果的Meta分析

Ｅffect of bone morphogenetic proteins-2/7 ｏn lumbar fusion：a meta-analysis

中文关键词:  骨形成蛋白  腰椎融合  系统评价

英文关键词:Bone morphogenetic proteins  Lumbar fusion  Systematic review

中文摘要:

  【摘要】 目的：系统评价应用骨形成蛋白（BMP-2及BMP-7）或传统植骨（包括自体骨、异体骨及人工骨）材料促进腰椎融合的效果。方法：计算机及手工检索相关的中英文杂志，检索相关文献的参考文献。收集所有关于应用骨形成蛋白进行腰椎融合与应用传统植骨方法进行腰椎融合术后临床效果比较的随机及类随机对照研究，并评价纳入研究的方法学质量。应用Cochrane协作网提供的RevMan　5.0.18统计软件进行统计分析。结果：共纳入符合标准的相关文献14篇。Meta分析表明，在腰椎前路及后路椎间融合和后外侧融合中应用BMP-2比传统植骨融合方式有更好的融合率；在后外侧融合中应用BMP-7与传统植骨融合方式相比融合率没有差异；与传统植骨融合方式相比，应用BMP-2/7进行腰椎融合的术后疗效没有差异。结论：应用BMP-2进行腰椎融合可提高术后融合率，但与疗效无关。

英文摘要:

  【Abstract】　Objective：To evaluate the efficacy of bone morphogenetic proteins-2/7（BMP-2/7）　versus traditional bony grafｔ（including autograft，allograft and artificial material graft） ｏｎ　lumbar fusion．Method：Randomized and quasi-randomized controlled trials related to application of BMP-2/7 on spine fusion versus traditional bony grafts　were searched on Pubmed，EBSCO，Springer and CBM（Chinese Biological and Medical database） database.The data of the ｅａｃｈ　article were evaluated.RevMan 5.0.18 provided by Cochrane was used to analysis the data.Result：Thirteen randomized or quasi-randomized controlled trials were included.The combined results showed that compared with the traditional standard treatment，BMP-2/7 used　in lumbar fusion ｗａｓ　proved：the higher fusion rate in the cases useｉｎｇ BMP-2 in anterior or posterior lumbar interbody fusion and posterolateral lumbar fusion than traditional bony graft，however application of BMP-7 could not lead to higher fusion rate in posterolateral fusion.Ｂetter outcome could not be associated with BMP-2/7.Conclusion：Compared with traditional standard treatment，BMP-2/7 can ensure higher fusion rate, while this is　unrelated to better outcome.