三七总皂甙对鼠脊髓损伤早期病理变化影响的观察

Histopathologic assessment of panax notoginseng saponins in rat spinal cord injury

中文关键词:  脊髓损伤,三七总皂甙,白质,少突胶质细胞,鼠

英文关键词:Spinal cord injury Panax notoginseng saponins White matter Oligodendrocyte Rat

中文摘要:

  Allen氏法250g·cm致伤60只Wistar大鼠T13～L1脊髓节段。伤后30min、2h、4h、第二及第三个24h分别腹腔注射三七总皂甙（PNS）100mg／kg及50mg／kg体重；另设二甲亚砜对照组及空白对照组。伤后30min、2h、6h、24h、1周及6周各取伤区脊髓组织送光、电镜检查。结果显示PNS治疗组脊髓灰质出血坏死较轻，周围白质大部存留，髓鞘残留，大量毛细血管和少突胶质细胞增生。提示PNS可减轻脊髓损伤后的灰质坏死，调节微循环和减轻继发性病理损害，为白质存活创造条件。

英文摘要:

  Experimental spinal cord injury(SCI) model was made by Allen's technique- Panax notoginseng saponins (PNS) was injected (50~ 100mg/kg ) intra peritoneally at 30min, 2h, 4h, the second and the third day after trauma. Pathological changes were compared with