应用聚氨基酸膜预防术后椎管粘连的实验报告

An experimental report on the prevetion of postopertive adhesion in spinal canal by poly leuceine methylglutamate glutamic membrane

中文关键词:  聚氨基酸膜 脊柱 外科手术 椎管粘连 预防

英文关键词:PLMGG Degrade Biological meterial Spinal canal Adhesion

中文摘要:

  １８只成年白兔平均分三组。椎扳切除后，实验组在硬膜外覆盖聚氨基酸膜，硅胶组用硅胶膜覆盖，空白组无覆盖物。术后３０ｄ、６０ｄ处死动物。结果显示：实验组及硅胶组的硬脊膜均光滑无增厚，硬膜外间隙未见新生纤维组织增生或粘连。聚氨基酸膜于１个月降解吸收，形成硬膜外＂空隙＂，硅胶则不吸收。空白组的硬脊膜增厚，硬膜外纤维组织增生或粘连明显，硬膜外间隙消失。因此，可降解的聚氨基酸膜能有效地预防术后椎管瘢痕粘连的形成，又不存留异物，是一种较理想的生物材料。

英文摘要:

  rabbits were divided into three groups.The epidural cavity following laminectomy covered by poly leucine methylglutamate glutamic(PLMGG) group,silicone rubber group and no coverings in the control group.The animals were sacrificed in 30 days and 60 days r