肿瘤压迫脊髓的实验研究

Experimental study of spinal cord compression by tumor

中文关键词:  肿瘤 脊髓压迫 血管造影

英文关键词:Tumor,Spinal cord compression,Electron microscopy,Angiography

中文摘要:

  将１０６Ｗａｌｋｅｒ ２５６癌细胞经度注射到８０只Ｗｉｓｔａｒ鼠Ｔ１３椎体的前方， ５～ １０天后出现脊髓压迫损害。应用ＣＴ和ＭＲＩ扫描对椎旁肿瘤进行了测量。电镜检查发现受压段脊髓毛细血管扩张，以后塌瘪，渗透性高，常有红细胞溢出。脊髓微血管造影发现，肿瘤压迫早期为静脉回流障碍，晚期主要是白质和灰质的缺血。脊髓水分测定，证实局部存在脊髓水肿。实验结果表明：脊髓内血循环障碍和轴索破坏是造成截瘫的重要因素。

英文摘要:

  Spinal cord compression was induced in 80 wistar rats by percutaneous inoculation of 106 cells of Walker 256 carcinoma anterior to the T13 vertebral body. The paravertebral tumor volume was mesured with CT and MRI scanning. The tumor invaded the epidural