脊髓损伤患者静脉血栓形成的临床相关因素分析

Analysis of clinical factors of venous thrombosis in patients with spinal cord injury

中文关键词:  脊髓损伤  静脉血栓  临床相关因素

英文关键词:Spinal cord injury  Venous thrombosis  Related clinical factors

中文摘要:

  【摘要】 目的：分析脊髓损伤患者伴发静脉血栓的临床相关因素，以更好地防治脊髓损伤患者的静脉血栓。方法：回顾性分析2013年12月～2015年1月在我院康复医学科住院的165例脊髓损伤患者的病历资料，按有无静脉血栓（venous thrombosis，VT）分为VT组和非VT组，分别统计两组患者年龄、性别、发病原因、既往史、骨折情况（无骨折、单纯椎体骨折及多发骨折）、脊髓损伤程度（ASIA分级）及平面（C1～C7、T1～T12及L1～S5）、并发症、手术开展时间、康复介入时间等临床指标，并采用SPSS 17.0统计软件进行统计分析，计数资料行X列表的卡方检验，检验标准α=0.05，P＜0.05为有统计学差异。采用两分类Logistics回归分析对相关危险因素进行相关性分析，P＜0.05表示有统计学意义。结果：入组患者165例，VT组82例，非VT组83例，其年龄、既往史、性别、临床并发症等基线指标组间无统计学差异（P>0.05）。手术开展时间单因素分析时两组间有统计学差异（χ2＝8.682，P=0.034），但在回归分析中显示无统计学差异（OR=0.432，P＝0.149）；骨折情况（OR=2.526）、脊髓损伤程度（OR=-0.637）、康复介入时间（OR=-0.706）方面两组间有统计学差异（P＜0.05）。结论：损伤程度重、多发骨折的脊髓损伤患者发生静脉血栓的风险相对较高，早期康复介入并采用综合预防和管理措施有利于减少静脉血栓形成，更有利于后期功能康复。

英文摘要:

  【Abstract】 Objectives: To analyze clinical features of spinal cord injury patients with venous thrombosis, in order to provide better prevention and treatment for these patients. Methods: 165 patients with spinal cord injury in rehabilitation department of our hospital from December 2013 to January 2015 were retrospectively collected and analyzed. The information included age, sex, history, cause, fracture status(no fracture, simple vertebrae fracture and multiple fracture), degree(ASIA grade) and level(C1-C7, T1-T12 and L1-S5) of spinal cord injury, complications, operation time and rehabilitation intervention time, etc. The results of this study were statistically analyzed by SPSS 17.0 statistical software. The chi-square test was used to count the data, and the standard α=0.05, P<0.05 was regard to be statistically different. Two categories of Logistics regression analysis were used to analyze the related risk factors, if P<0.05 showed there was statistical difference. Results: There were no significant differences in age, history, gender and clinical complications between two groups(P>0.05). According to the operation time, there was statistical difference between two groups by single factor analysis(χ2＝8.682, P=0.034), but there was no significant difference by regression analysis(OR=0.432, P＝0.149). There were significant differences in fracture status(OR=2.526), degree of spinal cord injury(OR=-0.637) and time of rehabilitation(OR=-0.706) between two groups(P<0.05). Conclusions: The risks of venous thrombosis are significant high among those patients who suffered from severe injury and multiple fracture. Early rehabilitation and comprehensive prevention and management measures are conducive to reduce venous thrombosis and promote functional recovery.