臭氧治疗对破裂型腰椎间盘突出症患者自身体液免疫的影响

Application of ozone on autoimmunity of patients with lumbar prolapsed disc

中文关键词:  腰椎间盘突出症  医用臭氧  体液免疫

英文关键词:Lumbar disc herniation  Medical ozone  Humoral immunity

中文摘要:

  【摘要】 目的：探讨医用臭氧对破裂型腰椎间盘突出症（LDH）患者自身体液免疫水平的影响。方法：选取50例破裂型LDH患者及50例健康成年人作为研究对象，比较两组血清中免疫球蛋白G（IgG）和M（IgM）含量，并应用医用臭氧微创治疗LDH患者，观察血清中IgG和IgM含量在治疗前后的变化。结果：破裂型LDH患者血清中IgG、IgM含量分别为16.04±2.58g/L及1.79±0.45g/L，较健康成年人的13.33±2.67g/L、0.89±0.34g/L均有显著升高（P<0.01）；经医用臭氧治疗3d后患者的IgG、IgM含量分别降至14.15±2.43g/L及1.43±0.39g/L，均较治疗前明显降低（P<0.01）。结论：医用臭氧能够在一定程度上抑制破裂型LDH患者的自身体液免疫水平，这可能是其治疗腰椎间盘突出症的作用机制之一。

英文摘要:

  【Abstract】　Objective：To investigate the use of ozone on autoimmunity of patients with lumbar prolapsed disc.Method：50 cases with lumbar prolapsed disc and 50 healthy adults were collected.The concentration levels of immunoglobulin G and M in peripheral blood by immunoturbidimetry between patients and healthy ones were compared，then lumbar disc herniation（LDH） patients underwent percutaneous intradiscal ozone-injection（PIOI），and the concentration levels of immunoglobulin G and M of these patients between pre-operation and post-operation were compared.Result：The immunoglobulin G and M level in peripheral blood of LDH patients were 16.04±2.58g/L and 1.79±0.45g/L respectively.Both were significantly higher than that of the healthy adults（13.33±2.67g/L and 0.89±0.34g/L）（P<0.01）.After operation，the levels were 14.15±2.43g/L and 1.43±0.39g/L for immunoglobulin G and M level respectively，both were significantly lower than those of preoperation（P<0.01）.Conclusion：Ozone for medical use can inhibit the auotoimmunity of patients with lumbar prolapsed disc，which remains one of the mechanisms for managing LDH.