李浩鹏,陈 杰,贺西京,徐思越,刘 宇.马尾受压后腰骶部脊髓中P75神经营养因子受体的表达及其与神经元凋亡的关系[J].中国脊柱脊髓杂志,2009,(10):753-757.
马尾受压后腰骶部脊髓中P75神经营养因子受体的表达及其与神经元凋亡的关系
Expression of P75 neurotrophic receptor in lumbosacral spinal cord after cauda equina compression and its relationship with neuron apoptosis
投稿时间:2006-06-29  修订日期:2009-09-15
DOI:10.3969/j.issn.1004-406X.2009.10.753.4
中文关键词:  马尾综合征  P75神经营养素因子受体  脊髓  神经元  凋亡  大鼠
英文关键词:Cauda equine syndrome  P75 neurotrophine receptor  Spinal cord  Neuron  Apoptosis  Rat
基金项目:国家自然科学基金资助项目(编号:30672136)
作者单位
李浩鹏 西安交通大学医学院第二附属医院骨二科 710004 陕西省西安市 
陈 杰  
贺西京  
徐思越  
刘 宇  
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中文摘要:
  【摘要】 目的:观察大鼠马尾受压后腰骶部脊髓中P75神经营养因子受体(P75 neurotrophic receptor,P75NTR)的表达,探讨P75NTR与前角神经元凋亡的关系。方法:48只雌性成年SD大鼠,随机分为正常组(n=6)、对照组(n=6)和实验组(n=36),正常组不作任何处理,对照组行假手术,实验组在L4平面置入半圆柱体硅胶棒,占椎管截面积约75%~80%,造成马尾急性受压。实验组分别于造模后1d、3d、5d、7d、14d、28d时取L4压迫节段近端脊髓组织(L2水平脊髓),正常组和对
英文摘要:
  【Abstract】 Objective:To investigate the expression of P75 neurotrophic receptor(P75NTR) at different time-point in lumbosacral spinal cord after cauda equina compression,and its relationship between it and the apop?鄄tosis of anterior horn neurons.Method:4
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