王新家,孔抗美,齐伟力.减压对慢性压迫性脊髓损伤大鼠ChAT表达的影响[J].中国脊柱脊髓杂志,2003,(3):.
减压对慢性压迫性脊髓损伤大鼠ChAT表达的影响
Influence of decompression on the expression of ChAT in chronic spinal cord injury of rats
  
DOI:
中文关键词:  脊髓损伤,胆碱乙酰转移酶,脊髓减压,机理
英文关键词:Spinal cord injury,Choline acetyltransferase,Decompression,Mechanism,
基金项目:
王新家  孔抗美  齐伟力
汕头大学医学院第二附属医院 515000广东省汕头市 (王新家,孔抗美)
,汕头大学医学院第二附属医院 515000广东省汕头市(齐伟力)
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中文摘要:
  目的:探讨手术减压对治疗慢性脊髓损伤的作用机理。方法:采用大鼠后路渐进性脊髓压迫动物模型,然后进行手术减压,观察其联合行为评分(CBS),并常规行病理及胆碱乙酰转移酶(ChAT)的免疫组化检测。结果:脊髓损伤后ChAT免疫组化阳性细胞数减少,CBS升高;经手术减压治疗后,ChAT阳性细胞数增多,CBS也改善,减压组与压迫组比较差异具有显著性(P<0.05)。结论:手术减压治疗的作用机制可能是其促进了脊髓运动神经元合成ChAT,从而合成更多的运动神经递质———乙酰胆碱,加速了实验动物行为功能的恢复。
英文摘要:
  Objective:To study the mechanisms of decompression on chronic spinal cord injury of rats.Method:A model of chronic spinal cord injury was made.After sixty days,the pressure installation were removed.A quantitive analysis was carried out on CBS and positiv
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