胡侦明,劳汉昌,张宝华,刘汉钧,舒钧,黎冠群.三七总皂甙对鼠脊髓损伤早期病理变化影响的观察[J].中国脊柱脊髓杂志,1997,(1):.
三七总皂甙对鼠脊髓损伤早期病理变化影响的观察
Histopathologic assessment of panax notoginseng saponins in rat spinal cord injury
  
DOI:
中文关键词:  脊髓损伤,三七总皂甙,白质,少突胶质细胞,鼠
英文关键词:Spinal cord injury Panax notoginseng saponins White matter Oligodendrocyte Rat
基金项目:
胡侦明  劳汉昌  张宝华  刘汉钧  舒钧  黎冠群
昆明医学院附二院骨科!云南省昆明市650101(胡侦明,劳汉昌,张宝华,舒钧)
,昆明医学院实验中心电镜室(刘汉钧)
,昆明医学院附二院病理科!云南省昆明市650101(黎冠群)
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中文摘要:
  Allen氏法250g·cm致伤60只Wistar大鼠T13~L1脊髓节段。伤后30min、2h、4h、第二及第三个24h分别腹腔注射三七总皂甙(PNS)100mg/kg及50mg/kg体重;另设二甲亚砜对照组及空白对照组。伤后30min、2h、6h、24h、1周及6周各取伤区脊髓组织送光、电镜检查。结果显示PNS治疗组脊髓灰质出血坏死较轻,周围白质大部存留,髓鞘残留,大量毛细血管和少突胶质细胞增生。提示PNS可减轻脊髓损伤后的灰质坏死,调节微循环和减轻继发性病理损害,为白质存活创造条件。
英文摘要:
  Experimental spinal cord injury(SCI) model was made by Allen's technique- Panax notoginseng saponins (PNS) was injected (50~ 100mg/kg ) intra peritoneally at 30min, 2h, 4h, the second and the third day after trauma. Pathological changes were compared with
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